Table 2.
Fetal arterial blood gas status during acute hypoxaemia with and without the NPY-Y, receptor antagonist
| Normoxia | Hypoxaemia | Recovery | |||||
|---|---|---|---|---|---|---|---|
| N15 | N45 | H15 | H45 | R15 | R45 | ||
| PHa | Saline | 7.35 ± 0.01 | 7.35 ± 0.01 | 7.32 ± 0.02 | 7.27 ± 0.02* | 7.25 ± 0.03* | 7.28 ± 0.01* |
| Antagonist | 7.34 ± 0 | 7.34 ± 0 | 7.31 ± 0.02 | 7.28 ± 0.04* | 7.25 ± 0.02* | 7.27 ± 0.02* | |
| Pa,CO2 (mmHg) | Saline | 51.0 ± 1.8 | 51.7 ± 1.5 | 51.2 ± 1.4 | 51.7 ± 0.7 | 49.5 ± 1.5 | 50.0 ± 1.3 |
| Antagonist | 51.6 ± 0.9 | 51.4 ± 0.6 | 52.4 ± 1.1 | 52.6 ± 1.3 | 51.4 ± 1.1 | 49.6 ± 0.9 | |
| Pa,O2 (mmHg) | Saline | 21.3 ± 0.9 | 21.7 ± 0.8 | 11.8 ± 0.3* | 12.2 ± 0.3* | 23.3 ± 1.7 | 21.3 ± 1.6 |
| Antagonist | 22.2 ± 0.8 | 22.2 ± 1.0 | 11.8 ± 0.4* | 12.4 ± 0.6* | 25.6 ± 1.2 | 21.6 ± 1.9 | |
| ABE (mequiv 1−1) | Saline | 2.0 ± 0.3 | 2.0 ± 0.3 | −0.5 ± 0.8 | −4.7 ± 1.3* | −8.2 ± 2.0* | −4.8 ± 1.5* |
| Antagonist | 1.8 ± 0.5 | 1.4 ± 0.4 | −0.4 ± 0.7 | −4.4 ± 1.8* | −9.6 ± 1.3* | −5.8 ± 0.9* | |
| Sat. Hb (%) | Saline | 61.6 ± 2.9 | 62.7 ± 2.3 | 29.4 ± 1.6* | 30.3 ± 1.9* | 58.2 ± 3.4 | 57.5 ± 3.5 |
| Antagonist | 60.5 ± 1.1 | 58.6 ± 2.5 | 30.2 ± 1.7* | 28.9 ± 1.9* | 59.9 ± 2.1 | 56.5 ± 3.3 | |
| Hb (g dl−1) | Saline | 8.9 ± 0.5 | 8.9 ± 0.5 | 9.9 ± 0.5* | 9.7 ± 0.5* | 8.6 ± 0.5 | 8.3 ± 0.4 |
| Antagonist | 8.0 ± 0.4 | 8.5 ± 0.4 | 9.4 ± 0.4* | 9.5 ± 0.3* | 8.7 ± 0.3 | 8.7 ± 0.3 | |
Values are means ± s.e.m. taken at 15 (N15) and 45 (N45) minutes of normoxia, 15 (H15) and 45 (H45) minutes of hypoxaemia and 15 (R15) and 45 (R45) minutes of recovery for 5 fetuses during vehicle infusion and during treatment with the selective NPY-Y1 receptor antagonist. Treatment started 20 min prior to the onset of acute hypoxaemia and ran continuously until the end of the hypoxaemic challenge (bar). Significant differences are:
P < 0.05, differences by post-hoc analysis indicating a significant main effect of time (one-way repeated measures ANOVA + Tukey test).
pHa, arterial pH; Pa,CO2 arterial CO2 partial pressure; Pa,O2, arterial O2 partial pressure; ABE, acid–base excess; Sat. Hb., percentage saturation of haemoglobin with oxygen; Hb, haemoglobin concentration.