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. 2002 Dec 13;546(Pt 3):655–664. doi: 10.1113/jphysiol.2002.032961

Figure 2. Metabotropic glutamate receptors (mGluRs) 1 (mGluR1) and 5 (mGluR5) contribute synergistically to activate a cationic conductance in CA3 pyramidal cells.

Figure 2

A, top traces show responses to DHPG in control conditions and bottom traces show responses to DHPG after application of either the mGluR1 antagonist LY367385 (LY), the mGluR5 antagonist 2-methyl-6-(phenylethynyl)pyridine hydrochloride (MPEP), or both. B, pooled data show that blocking either mGluR1 or mGluR5 reduced the response to DHPG by more than 50 % in CA3 pyramidal neurons. Only the block by the competitive antagonist LY367385 was reversible.