Figure 3. Effects of gonadectomy and sex steroid replacement on the integrated ACTH secretion (area under the curve, AUC) induced by LPS (100 µg (kg body wt)⁻¹, i.v. bolus) in male and female rats.

For abbreviations, see Table 1. *Statistically significant vs. the other male groups. †Statistically significant vs. the OVX, OVX + P and the three male groups. ‡Statistically significant vs. the sham ODX and ODX + T groups.