Table 3.

Characteristics of ¹²⁵I-IL-1β binding to MBH and AP homogenates in the eight experimental groups

		MBH		AP
Sex	Group	Kd (nM)	Bmax (fmol (mg protein)−1)	Kd (nM)	Bmax (fmol (mg protein)−1)
M	Sham ODX	2.4 ± 0.3	82 ± 9	2.5 ± 0.2	30 ± 4
	ODX	2.2 ± 0.2	143 ± 16*	2.4 ± 0.3	33 ± 5
	ODX + T	2.5 ± 0.3	76 ± 8	2.5 ± 0.3	29 ± 3
F	Sham OVX	2.3 ± 0.3	213 + 27†	2.3 ± 0.3	28 ± 4
	OVX	2.6 ± 0.4	130 ± 14‡	2.5 ± 0.3	31 ± 3
	OVX + E2	2.4 ± 0.3	260 ± 23‡	2.6 ± 0.2	32 ± 4
	OVX + P	2.4 ± 0.2	135 ± 18‡	2.3 ± 0.2	33 ± 3
	OVX + E2 + P	2.5 ± 0.2	220 ± 25†	2.4 ± 0.2	34 ± 4

Six separate binding experiments were performed in each group. For abbreviations, see Tables 1 and 2 and Fig. 4.

^*Statistically significant vs. the other male groups.

^†Statistically significant vs. the OVX, OVX + P and the three male groups.

^‡Statistically significant vs. the sham ODX and ODX + T groups.