Table 2.
Vascular function of control and protein-restricted pregnant offspring
| Aorta (n = 5) | Mesenteric (n = 7–9) | |||
|---|---|---|---|---|
| C Group | PR Group | C Group | PR Group | |
| Lumen diameter (μm) | — | — | 314.56 ± 22.84 | 338.34 ± 14.28 |
| Maximal contraction | ||||
| 125 mM KPSS (mN mm−1) | — | — | 2.7 ± 0.3 | 2.9 ± 0.2 |
| KCI (g force) | 0.92 ± 0.01 | 0.96 ± 0.01 | — | — |
| Phenylephrine (% KPSS) | 100 ± 1 | 101 ± 1 | 108 ± 2 | 103.0 ± 2 |
| % maximal relaxation | ||||
| Acetylcholine | 88 ± 5 | 97 ± 8 | 91 ± 2 | 85 ± 2 |
| Isoprenaline | 92 ± 6 | 84 ± 6 | 100 ± 1 | 87 ± 1*** |
| Isoprenaline + l-NAME | — | — | 72 ± 3††† | 77 ± 3††† |
| pEC50 (–log M) | ||||
| KCl | 1.53 ± 0.01 | 1.53 ± 0.01 | — | — |
| Phenylephrine | 7.05 ± 0.03 | 7.05 ± 0.02 | 5.83 ± 0.02 | 5.78 ± 0.03 |
| Acetylcholine | 7.76 ± 0.08 | 7.77 ± 0.03 | 8.23 ± 0.06 | 7.95 ± 0.05** |
| Isoprenaline | 7.50 ± 0.15 | 7.57 ± 0.12 | 7.86 ± 0.02 | 8.09 ± 0.04 |
| Isoprenaline + L-NAME | — | — | 7.42 ± 0.09††† | 7.21 ± 0.10†† |
**
P < 0.01 PR vs. C in same vascular bed (Student's t test)
***
P < 0.01 L-NAME vs. C in same vascular bed (Student's t test)
††
P < 0.001 L-NAME vs. control(Student's t test)
†††
P < 0.001 L-NAME vs. control(Student's t test)