Figure 4. Lack of the αCTxGI-resistant response to choline in denervated muscle from α7-null mice.

Choline-evoked depolarization was obtained after treatment with 0.1 µmαCTxGI in the denervated soleus muscles. A, traces showing averaged response to 10 mm choline in α7+/+ and α7-/- mice. Stimulation artifacts caused by the agonist applications (arrowheads) have been eliminated. B, peak amplitude of the αCTxGI-resistant depolarization by choline in α7+/+ and α7-/- mice. Data values represent the means ± s.e.m. (n = 17–24, 5–6 muscles, **P < 0.01, determined by unpaired t test).