Figure 2. Concanavalin-A (Con-A) but not postsynaptic density protein 95 (PSD-95) affects glutamate receptor (GluR)6 steady-state desensitization.

A, typical membrane currents evoked by 10 mm glutamate (250 ms duration, holding potential (V_H) =−20 mV) on outside patches expressing GluR6 receptors alone (left panel, patch no. 010712p1), co-expressed with PSD-95 (right panel, patch no. 010619p1) or following treatment with 10 μm Con-A (patch no. 000327p2) and 10 μm succinyl Con-A (sCon-A; patch no. 010713p2). B and C, plots summarizing the effect of lectin treatment and co-expression of PSD-95 on GluR6 steady-state responses (B) and the fast kinetic component of desensitization (C). All data are expressed as the mean ±s.e.m.