Figure 7. PSD-95 accelerates recovery from GluR6 receptor desensitization.

A, ten normalized test responses observed when GluR6 receptors were co-expressed with PSD-95 (1:10 ratio). As noted for control and Con-A conditions, test responses re-enter desensitization with slower kinetics during the early phase of recovery. B, summary plots comparing recovery of GluR6 responses from desensitization in control conditions (open circles) and with PSD-95 (filled circles). The time axis is plotted on a logarithmic scale to show the early phase of the recovery process. Insert: plot of the early phase of the recovery process showing that GluR6 channels recover faster from desensitization in the presence of PSD-95. The time axis is plotted on a linear scale. C, plots showing the contribution of conducting states G₁-G₃ to the macroscopic response for GluR6 receptors alone (upper panel) or when co-expressed with PSD-95 (lower panel). D, summary plot showing the values of rate constants r₁ and r₂ estimated from fits of data shown in B.