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A, InsP3 together with thapsigargin activates ICRAC in weak buffer whereas InsP3 alone is ineffective. B, InsP3 with cyclopiazonic acid, a structurally distinct SERCA pump blocker, is also effective. SERCA pump block alone (2 μm Thap + 0.1 mm EGTA) can also activate ICRAC, albeit at a much slower rate.
