Figure 2. The temperature dependency of the time course of inactivation.

Cells were depolarized from −100 mV in a cyclic pulse program with 40 ms test pulses in 15 mV steps. The current decay was best described by a sum of two exponentials yielding two time constants of inactivation, τ_h1 and τ_h2, with a relative weight of the faster time constant, τ_h1, of more than 90 %. τ_h1 (left column) and τ_h2 (right column) at 15, 25 and 35 °C in WT (A), M1360V (B) and R1448H (C).