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. 2003 Jan 17;547(Pt 3):913–929. doi: 10.1113/jphysiol.2002.034611

Figure 8. Effect of the PKC inhibitor Gö6976 on the TRH effects.

Figure 8

The time course of relative r-ERG current reduction by TRH and E-4031 following a 5 min treatment with 0.5 μm Gö6976 is shown in the upper right panel. Filled circles correspond to the current traces shown on the left. Note the almost complete absence of reversal of the TRH-induced inhibition after more than 20 min of hormone washout. A comparison of the TRH-induced reductions of the E-4031-sensitive r-ERG currents for control cells and cells treated with Gö6976 is shown in the lower left panel. Averaged values of the magnitude of current recovery upon TRH washout in the absence or the presence of Gö6976 is shown in the lower right panel. ***P = 0.0001.