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. 2003 Mar 7;548(Pt 2):485–492. doi: 10.1113/jphysiol.2002.037952

Figure 4. 8-OH-DPAT inhibits a TASK-1-like channel.

Figure 4

Experiments in voltage-clamp mode in the presence of TTX (1 μm) and CsCl (1 mm). A, I–V plot from the ramp protocol before (black) and after addition of 8-OH-DPAT (10 μm; red). The 8-OH-DPAT sensitive component (grey) showed mild outward rectification. B, normalized and averaged I–V plot from the ramp protocol before (black) and after addition of 8-OH-DPAT (10 μm; red) (n = 4). Inset: normalized current measured at −110 mV. The inhibition was statistically significant. C, normalized and averaged I–V plot before (black) and after changing to medium with low pH (green) (n = 7). The inhibition was significant (*). Subsequent addition of 8-OH-DPAT (10 μm; red) had no additional effect. D, normalized and averaged I–V plot before (black) and after addition of anandamide (blue) (n = 4). The inhibition was significant (*). Subsequent addition of 8-OH-DPAT (10 μm) had no additional effect (inset; red).