Figure 2. Selective properties of α1-AR-coupled membrane channels in LNCaP cells.

A, ramp-derived I-V relationships of PHE-evoked current in a representative cell sequentially exposed to divalent cation-free extracellular solution containing 135 mm Na⁺, Cs⁺, Li⁺ or K⁺. B, same as in A, but for another cell sequentially exposed to NMDG-based extracellular solution containing 10 mm Ca²⁺ (1), Mg²⁺ (2), Ba²⁺ (3), Sr²⁺ (4) or Mn²⁺ (5). C, I-V relationships of PHE-evoked current in representative cell in standard Cs⁺-based extracellular solution (2/Ca, 2/Mg) and following omission of Ca²⁺ and Mg²⁺ (0/Ca, 0/Mg).