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. 2003 Apr 4;548(Pt 3):823–836. doi: 10.1113/jphysiol.2002.036772

Figure 4. Stimulation of muscarinic and α1-adrenoreceptors converge on diacylglycerol-gated cationic channels.

Figure 4

A, development time course of inward current (measured at −100 mV) in the representative LNCaP cell in Cs+-based extracellular solution in response to the membrane-permeable DAG analogue, 1-oleoyl-2-acetyl-sn-glycerol (OAG, 100 μm) alone, and following co-application with PHE (50 μm); interventions marked with horizontal bars. B, ramp-derived I-V relationships of OAG (1) and OAG + PHE (2) currents acquired at the respectively numbered times on the time course in panel A, showing virtually no difference in amplitude or reversal potential. C and D, same as in A and B, respectively, but with the interaction of OAG and CCh in another representative LNCaP cell. E, quantification of the delay, development periods, and maximal densities for PHE-, CCh- and OAG-induced currents (mean ±s.e.m., n = 10–15).