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. 2003 Mar 14;548(Pt 3):723–730. doi: 10.1113/jphysiol.2003.040188

Figure 4. Responses mediated by GluR5-containing KARs are enhanced by mGluR stimulation.

Figure 4

A, DHPG, 20 μm (n = 54 cells, 9 dishes), increases the GluR5-mediated calcium signal (P < 0.05). This enhancement is prevented by the PKC inhibitor BIM. B, single example of a field of cells and pooled data showing that the mGlu5 agonist CHPG, 500 μm (n = 39 cells, 5 dishes), enhanced GluR5 calcium signalling, in a PKC-dependent manner (P < 0.001). These experiments were performed in the presence of cyclopiazonic acid (CPA) to prevent calcium mobilisation from intracellular stores by group I mGlu receptor stimulation. C, the inward current resulting from activation of GluR5-containing KARs by ATPA in perirhinal cortex neurones is enhanced (P < 0.05) by co-activation of group I mGlu receptors by DHPG (ATPA: 26 ± 3 pA; ATPA and DHPG: 57 ± 11 pA, n = 4).