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. 2003 Mar 21;548(Pt 3):765–775. doi: 10.1113/jphysiol.2002.037622

Figure 4. The κ-receptor-mediated Ih enhancement is independent of GIRK channel activation.

Figure 4

A, a graph showing the percentage increase in Ih tails induced by U69593 (300 nm) in the presence of BaCl2 (200 μm, n = 9). The inset shows current traces of Ih tails at −120 mV in the presence of either BaCl2 or BaCl2+ U69593. B, U69593-induced outward currents in control and in the presence of BaCl2 from the same cells as in A (n = 9). Holding potential was −60 mV. **P < 0.01 vs. control. C, current traces during a voltage step to −120 mV in the presence of either ZD7288 (1 μm) or ZD7288 + U69593 in a brain slice pre-treated with ZD7288 (1 μm). Note the absence of Ih in both conditions. D, U69593 (300 nm)-induced outward currents in normal cells (control, n = 39) and in ZD7288-treated cells (n = 14). E, current traces during a voltage step to −120 mV before (control) and during application of met-enkephalin (10 μm) in a secondary cell. Note the increase in GIRK conductance but not in the Ih.