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. 2003 Mar 28;549(Pt 1):107–120. doi: 10.1113/jphysiol.2002.038646

Figure 4. Internal K+ dependence of on- and off-rates for TBSb block.

Figure 4

A, the internal K+ dependence of the on-rate for internal TBSb block in the absence (□) and presence (•) of 100 mm external TEA. Rates determined as illustrated in Fig. 3. Continuous line and dashed line as described in the text. The dotted line connects the symbols representing the data obtained in the absence of external TEA and has no mechanistic meaning. B, the internal K+ dependence of the internal TBSb off-rate obtained in the absence (□) and presence (•) of 100 mm external TEA. Continuous line as described in the text. The dotted line connects the symbols representing the data obtained in the absence of external TEA and has no mechanistic meaning. Insets: examples of determinations of on-rate (left) and off-rate (right) in 20 mm (▴) and 135 mm (▿) internal K+. The very large block by 100 μm TBSb in 20 mm internal K+ makes computation of the off-rate unreliable (see eqations in Methods) and so is not included. Error bars not illustrated if smaller than symbol.