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Potency of inhibition of hDRA-mediated 36Cl− efflux into ND-96 solution
| Inhibitory drug | ID50 (μM) | Inhibition | (n) |
|---|---|---|---|
| Niflumic acid | 6.8±2.5 | — | (6) |
| Tenidap | 9.6±1.9 | — | (6) |
| UK5099 (100 μM) | — | 100% | (3) |
| NS1652 (20 μM) | — | 69±5% | (3) |
| WW781 (20 μM) | — | 39±14% | (3) |
| Hydroxycinnamate (1 mM) | — | 34% | — |
| DIDS (0.5 mM) | — | 26±5% | (3) |
| (2 mM) | — | 66±1% | (3) |
Values are means ± s.e.m. for (n) oocytes. Mean efflux rate constants (k) in the absence of drugs ranged between 0.014 and 0.035 min−1 in these experiments.
