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. 2003 Apr 4;549(Pt 2):387–397. doi: 10.1113/jphysiol.2002.038232

Figure 8. Extracellular pH does not affect extracellular anion dependence of Au(CN)2− block in R334H-CFTR.

Figure 8

The effect of changing the extracellular anion (from Cl− to gluconate or from Cl− to SCN−), quantified by the Kd(0) ratio as in Fig. 3D, appears independent of pH in R334 and is significantly reduced relative to wild-type at pH 7.4. Mean of data from 3–5 patches in each case.