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. 2003 Apr 4;549(Pt 2):387–397. doi: 10.1113/jphysiol.2002.038232

Figure 9. Mutation of R334 affects current rectification and anion selectivity.

Figure 9

A, rectification of the macroscopic I-V relationship, quantified as the rectification ratio as described in Methods, is significantly increased following mutagenesis of R334 (*P < 0.05; **P < 0.001). Furthermore, this rectification acquires pH dependence in R334H not seen in wild-type. Mean of data from 3–5 patches. B, relative SCN− permeability, estimated from the reversal potential with 150 mm NaSCN in the extracellular solution, was unaltered in most mutants but significantly increased (**P < 0.001) in R334L. Mean of data from 3–5 patches.