Figure 2. Effect of exogenous IL-10 on S. aureus-evoked fever.

The fever response of rats injected i.po. with S. aureus (3 × 10¹¹ cell walls kg⁻¹, circles, n = 10) or saline (triangles, n = 10), and IL-10 (200 μg kg⁻¹, filled symbols) or saline (1 ml kg⁻¹, open symbols). The results are presented as means ±s.e.m., n = 5. The arrow indicates the time of injection; the black bars indicate periods of darkness (lights out).