Skip to main content
. 2003 Apr 11;549(Pt 2):653–664. doi: 10.1113/jphysiol.2002.037291

Figure 3. Treatment with anti-IL-10 serum prolongs the duration of LPS-evoked fever.

Figure 3

A, i.po. injection of sheep anti-IL-10 serum (1 ml, filled symbols) or sheep pre-immune serum (PIS, 1 ml, open symbols) followed by injection (i.po.) of LPS (100 μg kg−1, circles) or saline (1 ml kg−1, triangles). The results are presented as means +s.e.m., n = 5. The arrow indicates the time of injection; the black bars indicate periods of darkness (lights out). B, fever indices (FIs, °C h, means ±s.e.m., n = 5) calculated from the time of injection for rats receiving: PIS + saline (grey columns); anti-IL-10 serum + saline (black columns); PIS + LPS (horizontal hatched columns); anti-IL-10 serum + LPS (open columns). FIs are time integrals of the change in body temperature from the pre-injection body temperature prevailing on the day of injection. Black bars indicate periods of darkness (lights out). NS, not significant; ***P < 0.001 PIS + LPS vs. anti-IL-10 + LPS; ANOVA (Tukey post hoc test) for the same time frame. $$$P < 0.001 PIS + saline vs. PIS + LPS; ANOVA (Tukey post hoc test) for the same time frame.