Skip to main content
. 2003 Apr 17;549(Pt 3):809–821. doi: 10.1113/jphysiol.2002.033290

Figure 3. Orexin-induced depolarisation is reduced by the OX1R anatagonist SB334867A.

Figure 3

A, samples of a continuous whole-cell recording showing orexin A-induced reversible depolarisations in SPN that were not subject to desensitisation. B, orexin A induced a membrane depolarisation sufficient to reach threshold for firing in another SPN, an effect that was subsequently reduced following exposure of the slice to SB334867A (1 μm). C, summary histogram of pooled orexin-induced depolarisations in the presence and absence of SB334867A (1–10 μm). The error bars represent the s.e.m.