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. 2003 Apr 11;549(Pt 3):889–901. doi: 10.1113/jphysiol.2003.039750

Figure 7. Effects of somatostatin-14 and bombesin on PRL-2903-stimulated gastric acid secretion in wild-type mice.

Figure 7

In urethane-anaesthetized wild-type mice, gastric acid secretion was stimulated with PRL-2903 (bolus of 1.5 mg kg−1 and infusion of 1.5 mg kg−1 h−1 for 2 h). Ten minutes after starting the i.v. infusion of PRL-2903 a 1 h infusion of somatostatin-14 (A), bombesin (B) or vehicle was started. Acid secretion was monitored at 10 min intervals throughout the experimental time. Left panels show time course changes in acid secretion. Right panels show cumulative acid output for the different treatments. * P < 0.05vs. respective basal secretion. Somatostatin-14: F3,10 = 31.999, P < 0.001. Bombesin: F3,14 = 17.379, P < 0.001.