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. 2003 May 9;550(Pt 1):181–189. doi: 10.1113/jphysiol.2003.043273

Figure 5. Neurally released NO inhibits regenerative potentials via cyclic-GMP in the circular layer of guinea-pig antrum.

Figure 5

The left-hand panels show the effect of NOLA (10 μM) on nitrergic inhibition of regenerative potentials. A regenerative potential (Aa) was abolished by nitrergic nerve stimulation (10 impulses at 5 Hz; Ab). Fifteen minutes after adding NOLA, the same train of stimuli failed to abolish the regenerative potential (Ac); resting potential −62 mV throughout. The right-hand panels show the effect of ODQ (1 μM) on nitrergic inhibition of regenerative potentials. A regenerative potential (Ba) was abolished by nitrergic nerve stimulation (10 impulses at 5 Hz; Bb). Seven minutes after adding ODQ, the same train of stimuli no longer abolished the regenerative potential (Bc); resting potential −64 mV throughout. Time, voltage and current calibration bars apply to all recordings. Nifedipine (1 μM), atropine (1 μM) and apamin (0.1 μM) were present throughout.