Table 1.

Kinetic analysis of MeHg-induced giant slow inward currents recorded from cerebellar Purkinje cells in slices

Giant response	Fast*	Slow
Rise time (ms)†	43 ± 25	157 ± 168
Peak amplitude (pA)	−620 ± 537	−193 ± 120
Rate of rise (pA ms−1)‡	−17 ± 16	−2 ± 1.44
Duration (ms)‖	821 ± 576	1447 ± 921
τ (pA ms−1)¶	182 ± 200	460 ± 538
Number of events	15	15

^*The giant slow inward currents were arbitarily divided into two groups: fast and slow responses based on their rising rate. Responses with rates of rise < 5 pA ms⁻¹ were identifies as slow responses, while those with rates of rise > 5 pA ms⁻¹ were classifies as fast responses. Responses were pooled for all three concentrations of MeHg tested (10, 20 and 100 μm). All values are expressed as means ±s.e.m.

^†Rise time is defined as the time requires from the baseline to the peak amplitude.

^‡Rate of rise is defined as peak amplitude/rise time.

^‖Duration of response is defined as the time from the start point to the end point of response.

^¶Decay of gaint responses was fitted using Clampfit fitting program with a single exponential.