Table 1.
The effect of exercise on the VEGF content and endothelial cell proliferative effect of mucsle dialysate without (Control) and with (ASA) cyclooxygenase inhibition
| First part | Second part | |||||
|---|---|---|---|---|---|---|
| Exercise protocol | Rest | Exercise | Recovery | Rest | Exercise | Recovery |
| VEGF (pg ml−1) | ||||||
| Control | 28.5 ± 11.3 | 126.6 ± 27.8+ | 86.0 ± 21.7 | 66.6 ± 19.5 | 363.2 ± 46.5* | 115.6 ± 22.4 |
| ASA | 59.4 ± 27.5 | 216.5 ± 18.1* | 118.1 ± 21.0 | 101.2 ± 22.4 | 408.2 ± 31.1* | 154.6 ± 25.8 |
| Endothelial cell proliferation, dialysate from 960 kDa probes (% of perfusate) | ||||||
| Control | 189.6 ± 56.2 | 413.7 ± 97.5 | 191.1 ± 48.9 | 328.0 ± 43.1 | 521.9 ± 135.8 | 310.8 ± 88.8 |
| ASA | 310.1 ± 36.0 | 675.9 ± 54.0* | 403.4 ± 56.8 | 367.9 ± 39.3 | 654.4 ± 54.2* | 412.6 ± 65.9 |
| Endothelial cell proliferation, dialysate from 5 kDa probes (% of perfusate) | ||||||
| Control | 143.8 ± 50.1 | 311.5 ± 73.5 | 310.0 ± 73.5 | 274.9 ± 30.4 | 392.6 ± 99.9 | 280.1 ± 69.2 |
| ASA | 210.8 ± 27.7 | 396.2 ± 68.5* | 410.7 ± 58.2 | 302.3 ± 39.2 | 4445.5 ± 56.1* | 358.1 ± 42.7 |
In the ASA group cyclooxygenase was inhibited after the first part of the protocol. Data from dialysate obtained during work are means of first and second sampling period of the exercise bout.
*
P < 0.05, vs. rest (mean ±s.e.m.).