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. 2003 May 30;550(Pt 2):385–399. doi: 10.1113/jphysiol.2003.043091

Figure 4. pH dependence of the csNSC current.

Figure 4

A, example traces showing the csNSC currents activated at pH 6.5, 7.5 and 8.5 in the same neuron. Neurons were perfused with different pH solutions for at least 2 min before activating the csNSC current. A decrease in pH to 6.5 inhibited the current while an increase in pH to 8.5 potentiated the current. B, summary data showing the amplitude of the csNSC currents activated at different pH values(397 ± 74 pA at pH 7.5; 206 ± 35 pA at pH 6.5; and 584 ± 87 pA at pH 8.5, n = 7). ** P < 0.01 when compared with pH 7.5 group. C, prolonged current traces demonstrate that both the rate of onset and the steady state of the csNSC current are affected by pHo. D, example traces showing the inhibition of the csNSC currents by low pH in the absence and presence of 1 mM Mg2+. E, example traces and exponential fits showing the effect of pH on the activation time constant (τ) of the csNSC currents.