Figure 7. Effects of ACE inhibition in Ovx-diabetic rats with oestrogen replacement.
Currents were recorded in cells obtained 10 days after induction of diabetes with STZ and following 17 days of oestradiol in the drinking water. Ovariectomy was performed 4 weeks before experiments. Mean current densities are plotted against membrane potential for Ipeak (A) and Isus (B) in the absence of (•) or following incubation (5–9 h) with 1 μM quinapril (▪). Restoring oestradiol to Ovx rats abolishes the effects of ACE inhibition on both currents, as in normal female rats.