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. 2003 Jun 13;550(Pt 3):785–800. doi: 10.1113/jphysiol.2003.042572

Figure 6. Picrotoxin and Zn2+-sensitivity of GABA-induced currents.

Figure 6

A and C, superimposed GABA-induced currents under control conditions and in the presence of increasing picrotoxin (A) or Zn2+ concentrations (B). Progenitors were recorded with an ATP-regenerating solution from a holding potential of −70 mV and GABA was pressure applied at 100 μm. B and D, GABA-induced current amplitudes normalized to the peak amplitude of the control responses and plotted as a function of the corresponding [picrotoxin] (B) and [Zn2+] (D). A fit to a sigmoidal logistic equation gave an IC50 of 346 μm for picrotoxin and 34 μm for Zn2+.