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. 2003 Jun 17;550(Pt 3):679–691. doi: 10.1113/jphysiol.2003.043810

Figure 6. Effect of PS concentration on onset and offset of block in hippocampal neurons.

Figure 6

A-C, protocol was similar to that used in Fig. 5, except that GABA was kept constant at 5 μm, and PS concentration was varied from 2.5 to 20 μm. Statistical differences were evaluated with an ANOVA and are denoted by asterisks (P < 0.05). There was an effect of PS concentration on degree of block and a significant effect of PS on onset but not offset time constant (n = 14–22 cells at each concentration). D–F, picrotoxinin (PTXNIN; 10 μm) was substituted for PS in the experimental protocol. Note that there was a significant effect of picrotoxinin concentration on both the degree of block and the onset time constant (n = 4 cells).