Figure 5. The Na⁺–Ca²⁺ exchange inhibitor KB-R7943 protects against chemically induced hypoxia and reoxygenation-induced Ca²⁺ overload in rat ventricular myocytes.

[Ca²⁺]_i measurements in 15 mm [K⁺]_o (i) under baseline conditions, and (ii) during 8 min chemically induced hypoxia, (iii) followed by 8 min reoxygenation. KB-R7943 (5 μm), a Na⁺–Ca²⁺ exchanger inhibitor, was applied during reoxygenation. * P < 0.05 vs. control (15 mm [K⁺]_o), n = 6 experiments, 20 and 29 cells.