Figure 2. Effect of A1 and GABA_B receptor activation on miniature GABAergic IPSCs (mIPSCs).

A top, representative traces showing mIPSC activity under control conditions (left) and in the presence of adenosine (10 μm, right). A bottom, cumulative probability histograms of time intervals between successive mIPSCs (left panel) and amplitudes of mIPSCs (right panel), before and during adenosine (10 μm) application. Adenosine shifted significantly the distribution of the inter-event intervals to the right (Kolmogorov-Smirnov test, P < 0.05), indicating a decrease in mIPSC frequency, but did not significantly alter the distribution of mIPSC amplitudes. B top, effect of the GABA_B receptor agonist SKF 97541 (1 μm) on GABAergic mIPSCs. In a neurone displaying GABAergic mIPSCs under control conditions (left panel), SKF 97541 (1 μm) reduced the frequency of the synaptic currents (right panel). B bottom, cumulative probability histogram of time intervals between successive mIPSCs (left panel) and amplitudes of mIPSCs (right panel), before and during SKF 97541 (1 μm) application. SKF 97541 significantly changed the distribution of the inter-event intervals (Kolmogorov-Smirnov test, P < 0.05), indicating an decrease in mIPSC frequency, but had no significant effect on the distribution of mIPSC amplitudes. The recordings were performed at a HP of −60 mV and in the presence of 0.5 μm TTX.