Table 1.

Femoral blood variables at rest, during handgrip exercise and after 5 min of recovery when exposed to normoxia, hypoxia, CO inhalation combined with normoxia and CO inhalation combined with hyperoxia

	Normoxia			Hypoxia
	Rest	Exercise	Recovery	Rest	Exercise	Recovery
[Hb] (gl−1)
Arterial	144 ± 4	143 ± 5	144 ± 4	143 ± 3	145 ± 4	145 ± 4
Venous	145 ± 4	143 ± 4	142 ± 3	144 ± 3	144 ± 3	145 ± 4
COHb (%)
Arterial	2.2 ± 0.1	2.2 ± 0.1	2.2 ± 0.1	2.0 ± 0.1	1.8 ± 0.1	1.8 ± 0.1
Venous	2.0 ± 0.1	2.0 ± 0.1	2.0 ± 0.1	1.8 ± 0.1	1.7 ± 0.1	1.8 ± 0.1
O2 sat (%)
Arterial	99.1 ± 0.2	99.2 ± 0.2	98.6 ± 0.5	79.7 ± 1.4*	70.3 ± 3.4*	70.3 ± 2.7*
Venous	75.8 ± 3.8	80.2 ± 4.2	79.0 ± 3.4	58.8 ± 4.8*	55.3 ± 4.2*	55.5 ± 4.9*
O2<Hb (ml l−1)
Arterial	193 ± 6	193 ± 6	193 ± 6	155 ± 4*	139 ± 7*	139 ± 7*
Venous	150 ± 9	156 ± 8	152 ± 7	115 ± 10*	109 ± 8*	109 ± 10*
PO2 (mmHg)
Arterial	113 ± 8	116 ± 8	116 ± 7	39 ± 1*	34 ± 2*	34 ± 2*
Venous	39 ± 4	45 ± 4	42 ± 3	31 ± 2*	27 ± 2*	27 ± 2*
CTO2 (ml l−1)
Arterial	196 ± 7	197 ± 6	197 ± 6	156 ± 4*	140 ± 7*	140 ± 7*
Venous	150 ± 9	157 ± 8	153 ± 7	116 ± 10*	109 ± 8*	110 ± 10*
PCO2 (mmHg)
Arterial	42 ± 1	41 ± 1	42 ± 1	37 ± 2*	37 ± 1*	37 ± 1*
Venous	47 ± 1	46 ± 1	46 ± 1	41 ± 2*	41 ± 1*	41 ± 1*
pH
Arterial	7.40 ± 0.01	7.41 ± 0.01	7.40 ± 0.01	7.45 ± 0.01*	7.46 ± 0.01*	7.45 ± 0.01*
Venous	7.39 ± 0.01	7.39 ± 0.01	7.38 ± 0.01	7.43 ± 0.01*	7.43 ± 0.01*	7.43 ± 0.01*
	CO + normoxia			CO + hyperoxia
	Rest	Exercise	Recovery	Rest	Exercise	Recovery
[Hb] (g l−1)
Arterial	143 ± 4	145 ± 4	143 ± 4	145 ± 4	145 ± 4	144 ± 4
Venous	142 ± 4	143 ± 4	142 ± 4	144 ± 4	142 ± 4	142 ± 4
COHb (%)
Arterial	22.6 ± 0.5*†	23.4 ± 0.6*†	22.9 ± 0.7*†	23.8 ± 0.5*†	23.1 ± 0.8*†	23.3 ± 0.9*†
Venous	22.7 ± 0.5*†	23.6 ± 0.5*†	23.5 ± 0.5*†	24.2 ± 0.5*†	23.9 ± 0.7*†	24.0 ± 0.8*†
O2 saturation (%)
Arterial	99.0 ± 0.2*	99.0 ± 0.2†	98.8 ± 0.2†	100.0 ± 0.0†	99.9 ± 0.0†	99.8 ± 0.1†
Venous	74.2 ± 3.4†	78.9 ± 1.7†	78.2 ± 3.4†	80.0 ± 4. 1†	82.9 ± 4.4†	82.7 ± 4.0†
O2 Hb, (ml l−1)
Arterial	152 ± 4*	153 ± 5*	151 ± 5*	153 ± 4*	155 ± 5*	153 ± 6*
Venous	112 ± 4*	119 ± 2*	117 ± 6*	120 ± 3*	124 ± 5*	123 ± 3*
PO2 (mmHg)
Arterial	103 ± 4†	118 ± 8†	117 ± 12†	609 ± 15*†	623 ± 19*†	590 ± 20*†
Venous	31 ± 2*	33 ± 2*	34 ± 2*	41 ± 3	44 ± 3	45 ± 2
CTO2 (ml l−1)
Arterial	155 ± 4*	157 ± 5*	155 ± 5*	172 ± 4*	173 ± 5*†	171 ± 6*†
Venous	113 ± 4	119 ± 2	118 ± 6	121 ± 3	125 ± 5	124 ± 3
PCO2 (mmHg)
Arterial	41 ± 1†	41 ± 1†	41 ± 1†	40 ± 1†	39 ± 1†	39 ± 1†
Venous	45 ± 1†	45 ± 1†	45 ± 1†	47 ± 1†	45 ± 1†	45 ± 1†
pH
Arterial	7.41 ± 0.01†	7.41 ± 0.01†	7.41 ± 0.01†	7.41 ± 0.02†	7.43 ± 0.01†	7.43 ± 0.01†
Venous	7.39 ± 0.01†	7.39 ± 0.01†	7.39 ± 0.01†	7.38 ± 0.02†	7.39 ± 0.02†	7.39 ± 0.01†

Values are means ± s.e.m. for 7 subjects.

^*Significantly different from normoxia, P < 0.05.

^†Significantly different from hypoxia, P < 0.05.