Figure 4. Effects of I.P. injection of LPS at 100 μg kg⁻¹ on T_c in WT (A), EP₁ receptor KO (B) and EP₃ receptor KO (C) mice.

Mice were injected with LPS (•) or 0.9 % saline (○) at time zero. The data are expressed as differences from the T_c at time zero, which is shown in the figure. Each point represents mean ±s.e.m.n = number of animals. Bar shows dark period. Symbols represent level of significance when compared with 0.9 % saline-injected control at each time point. *P < 0.05; **P < 0.01.