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. 2003 Jul 23;552(Pt 1):253–264. doi: 10.1113/jphysiol.2003.048173

Table 2.

Genes involved in glucose metabolism and insulin signalling in the subcutaneous white adipose tissue of lean (C57BL/6J) and obese (C57BL/6J-Lepob) mice exhibiting a twofold or greater change after exposure to IH for 5 days

n GenBank accession number Name Up (+) or down (−) regulation (fold difference)

Lean mice Obese mice
1 AI882416 Leptin +3.3 NC
2 M21247 Uncoupling protein 1 NC −5.6
3 U50413 Phosphatidylinositol-3-kinase, p85 alpha subunit −2.2 NC
4 X51975 Interleukin 6 receptor alpha −6.4 NC
5 AI574278 Insulin degrading enzyme −7 NC
6 AV023068 Caveolin 3 −15.7 +4.2

NC, no change or less than twofold difference was found in comparison with intermittent air control. IH, intermittent hypoxia.