Table 3.

Body weight, daily food intake and fasting blood glucose of obese (C57BL/6J-Lep^ob) mice during exposure to IH or IA for 12 weeks

		IH	IA
Body weight (g)	Baseline	44.4 ± 1.8	45.0 ± 1.4
	Week 4	51.5 ± 1.4*	52.4 ± 0.6*
	Week 8	55.9 ± 2.0*	55.5 ± 1.3*
	Week 12	60.1 ± 2.3*	60.3 ± 1.3*
Daily food intake (g)	Baseline	5.5 ± 0.2	5.5 ± 0.2
	Week 4	5.1 ± 0.4	5.1 ± 0.2
	Week 8	5.3 ± 0.2	5.3 ± 0.4
	Week 12	4.9 ± 0.1	4.6 ± 0.3
Fasting blood glucose (mg dl−1)	Baseline	373 ± 41	349 ± 24
	Week 4	245 ± 23*	242 ± 33*
	Week 8	233 ± 39*	205 ± 32*
	Week 12	200 ± 13*	185 ± 34*

IH, intermittent hypoxia; IA, intermittent air. The age at of the animals at the onset of the experiment was 9 ± 1 week for both the IH (n = 5) and IA (n = 7) groups. Statistical differences were determined by two-way ANOVA across the intervention (IH vs. IA) and time (0, 4, 8 and 12 weeks).

^*P < 0.02 for difference between baseline and weeks 4, 8 or 12.