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. 2003 Aug 8;552(Pt 2):379–391. doi: 10.1113/jphysiol.2003.046441

Figure 9. Activation of PKC prevents cAMP-stimulated activation of BK channels.

Figure 9

Representative time-course plot of ‘low’ activity BK channel open probability in patches pretreated with 0.8 μM PKC catalytic subunit and 100 nM PMA (open horizontal bar), before application of cAMP (filled horizontal bar) in the presence of 3 nM okadaic acid (ok, shaded bar). Under these conditions cAMP has no effect on channel open probability. In this patch after washout (vertical open dashed bar, wash) a subsequent cAMP application in the presence of 3 nM okadaic acid resulted in a sustained increase in channel open probability.