Table 1.

Compartmental localization of the main mitochondrial source of superoxide anion

Component	Localization	References
Complex I	Inner membrane/	(Turrens & Boveris, 1980; Turrens et al. 1982;
(NADH dehydrogenase)	inner side	Genova et al. 2001; Kushnareva et al. 2002)
Complex II	Inner membrane/	(Zhang et al. 1998; Lenaz, 2001)
(succinate dehydrogenase)	inner side
Complex III	Inner membrane/	(Boveris et al. 1976; Cadenas et al. 1977;
(ubiquinol-cytochrome c reductase)	inner side	Turrens et al. 1985)
Complex III	Inner membrane/	(Han et al. 2001; Starkov & Fiskum, 2001)
(ubiquinol-cytochrome c reductase)	outer side
External NADH dehydrogenase	Inner membrane/	(Fang & Beattie, 2003)
(yeast)	outer side
Glycerolphosphate dehydrogenase	Inner membrane/	(Drahota et al. 2002)
	outer side
Dehydroorotate dehydrogenase	Matrix	(Forman & Kennedy, 1976)
Mono amino oxidase	Outer membrane/	(Hauptmann et al. 1996; Cadenas & Davies, 2000)
	inner side