Table 2.

Effect of dietary manipulation on mice glycaemia

Diet	Wild-type mice mm±s.e.m.(n)	GLUT2-null mice mm±s.e.m.(n)	Wild/null
LC	5.10 ± 0.72(26)a	4.43 ± 0.83(14)e	*
HG	7.04 ± 0.94(25)c	6.60 ± 1.44(32)f	n.s.
HF	7.63 ± 1.27 (34)c	5.44 ± 1.10(41)g	***
HF + fructose bolus	11.93 ± 2.38(18)d	8.27 ± 1.60(20)h	***
Standard chow	5.93 ± 0.66 (13)b	6.71 ± 1.05 (6)f	n.s.

Mice had free access to the different diets for 5 days. Glucose was measured from tail blood at 9:00 a.m. The levels of glycaemia of fructose-fed mice were measured before (HF) and 30 min after a fructose bolus in the stomach (HF + fructose bolus) and were statistically different P < 0.001 in both GLUT2-null and wild-type mice. Statistical significance

^***p < 0.001 and

^*P < 0.05 comparing wild-type and GLUT2-null mice for each diet. Letters indicate statistically significant differences relative to sugar (HG, HF, HF + fructose bolus and standard chow) in the diet as compared with low carbohydrate supply (LC) in wild-type animals: ^bP < 0.01, ^a,c,dP < 0.001; and GLUT2-null mice: ^e,g,hP < 0.0001, ^fP < 0.05.