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. 2003 Aug 29;553(Pt 1):281–292. doi: 10.1113/jphysiol.2003.049940

Table 5.

Forearm and systemic haemodynamics for moderate exercise before and after l-NAME (protocol 5)

Adenosine Exercise


Variable Vasoconstrictor Time Pre l-NAME Post l-NAME Pre l-NAME Post l-NAME
FBF (ml min−1) Phenylephrine Baseline 28 ± 2 20 ± 4* 31 ± 5 18 ± 7
(n = 4) Pre-phenylephrine 143 ± 46 88 ± 24 185 ± 16 164 ± 15
Post-phenylephrine 96 ± 35 57 ± 19 163 ± 8 151 ± 22
Clonidine Baseline 36 ± 7 26 ± 4 38 ± 7 23 ± 3 *
(n = 5) Pre-clonidine 148 ± 31 92 ± 29* 205 ± 21 188 ± 19
Post-clonidine 78 ± 15 45 ± 12* 185 ± 25 171 ± 25
FVC (ml min−1 (100 mm Hg)−1) Phenylephrine Baseline 31 ± 2 21 ± 4* 35 ± 5 18 ± 7*
Pre-phenylephrine 166 ± 52 94 ± 28 194 ± 14 163 ± 17*
Post-phenylephrine 107 ± 37 59 ± 20 167 ± 15 146 ± 22
Clonidine Baseline 42 ± 8 27 ± 5* 44 ± 9 24 ± 4 *
Pre-clonidine 172 ± 35 101 ± 33* 226 ± 27 188 ± 21*
Post-clonidine 89 ± 17 47 ± 12* 198 ± 32 168 ± 27*
MAP (mmHg) Phenylephrine Baseline 90 ± 2 95 ± 2 90 ± 1 99 ± 3*
Pre-phenylephrine 86 ± 1 95 ± 2 95 ± 3 101 ± 2
Post-phenylephrine 89 ± 2 96 ± 2* 97 ± 4 104 ± 1
Clonidine Baseline 89 ± 2 94 ± 1 88 ± 1 99 ± 2*
Pre-clonidine 86 ± 2 92 ± 1 91 ± 3 100 ± 3 *
Post-clonidine 89 ± 3 96 ± 1* 96 ± 4 103 ± 2
*

P < 0.05 post vs. pre l-NAME within same hyperaemic condition

P < 0.05 exercise vs. adenosine within same l-NAME condition.