Figure 3. Fatigue is accelerated in CK^−/− muscle during repeated contractions in the presence of cyanide.

EDL muscles were stimulated with 330 ms tetani at 1 s intervals. Values are means ± s.e.m. for CK^−/− (n = 6, unfilled circles) or WT (n = 8, filled circles) muscles. Other than the first tetanus, differences between groups are significant during all contractions (P < 0.01–0.001).