Table 1.
Dimensions of jejunal enterocytes of hamster, rat and human used to calculate the cross-sectional area and length of the paracellular pathway
Non-absorbing | Absorbing | |||||||
---|---|---|---|---|---|---|---|---|
rs | rb | xb | Vcell | rs | h | Vcell | rb | |
Hamster | 4.75 | 4.00 | 21 | 1503* | 4.75 | 4 | 1040* | 2.4 |
Rat | 3.65 | 3.1 | 28 | 1181* | 3.65 | 5* | 825* | 1.9* |
Human | 5.5 | 4.80 | 36 | 3500* | 5.50 | 6* | 2452* | 3.0* |
Measured values are shown in plain type
indicates calculated values. All values are given in μm or μm3, as appropriate. On the basal side of the tight junction, the cells are treated as truncated cones with radii of rs at the level of the tight junction and rb at the level of the basement membrane. The height of the cone is xb and the distance from the brush border to the basal side of the tight junction is h (see Fig. 2A). Vcell, volume of cell.