Figure 5. Activation of PKC reduces the EPSC inhibition induced by DCG IV.

A and B, superimposed traces obtained from one experiment showing the inhibition of EPSCs by DCG IV (1 µm) in the absence (w/o PMA, A) and presence (w/ PMA, B) of PMA (2 µm). Note that PMA markedly prevents DCG IV-induced inhibition of EPSCs. C, summary bar graph indicating that the PKC activator PMA partially prevents DCG IV-induced inhibition of EPSCs. * Significant difference from control (n = 12; P = 0.002).