Table 1.
Summary of total CA1 apical dendritic spine densities
| Group | Dendritic segments | Dendritic length (μm) | Spine density per 10 μm | Slices | Cells |
|---|---|---|---|---|---|
| Serum-free | 54 | 2200.75 | 6.87 ± 0.22 | 4 | 7 |
| BDNF | 76 | 2072.46 | 9.46 ± 0.22* | 4 | 8 |
| TTX | 77 | 2344.57 | 6.46 ± 0.1 7 | 3 | 6 |
| TTX-BDNF | 66 | 1844.64 | 8.97 ± 0.20*† | 4 | 6 |
| BoNT/C | 49 | 1650.65 | 5.89 ± 0.21* | 3 | 5 |
| BoNT/C-BDNF | 40 | 1292.77 | 8.33 ± 0.33*† | 3 | 4 |
| 20% HSM | 23 | 885.97 | 11.17 ± 0.36* | 3 | 4 |
BDNF, brain-derived neurotrophic factor; BoNT/C, botulinum neurotoxin C; HSM, horse serum. Total spine density is expressed as mean ±s.e.m. normalized to 10 μm dendritic length.
*
Significant difference (P < 0.05) compared to serum-free control values
†
significant difference (P < 0.05) compared to that treatment group's condition control values (i.e. TTX-BDNF vs. TTX).