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. 2008 Jan 28;111(9):4771–4779. doi: 10.1182/blood-2007-08-105072

Figure 3.

Figure 3

Loss of a c-Myb allele has modest effects on colony formation of bone marrow progenitors. Colony formation assays were performed using (A) enriched Lin− marrow cells (5 × 103 cells/plate) plated in methylcellulose in the presence of GM-CSF (P = .015); (B) Lin−Sca-1+ marrow cells (5 × 103cells/plate) plated in methylcellulose in the presence of IL-3, IL-6, and KL (P = .008); and (C) Lin−Sca-1+Kit+ marrow cells (2.5 × 105/plate) plated in methylcellulose in the presence of optimal (IL-3, 6 ng/mL; IL-6, 10 ng/mL; KL, 50 ng/mL) or suboptimal (1/10th) cytokine concentrations; P = .011 and P ≤ .001, respectively. Representative of 3 different experiments performed in duplicate.