Table 2.
Pre-hypoxia | Recovery | Post-infusion | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Baseline | infusion | Hypoxia | with infusion | recovery | |||||||
Mean | s.e.m. | Mean | s.e.m. | Mean | s.e.m. | Mean | s.e.m. | Mean | s.e.m. | ||
PO2 (mmHg) | Control | 22.4 | 1.1 | 22.3 | 1.2 | 12.1 | 0.4† | 22.0 | 1.2 | 20.4 | 0.9 |
8-SPT | 21.4 | 1.0 | 22.1 | 1.4 | 11.0 | 0.6† | 22.6 | 0.9 | 22.8 | 1.4 | |
DPCPX | 21.7 | 1.0 | 18.3 | 1.9 | 10.9 | 1.0† | 19.6 | 2.6 | 23.1 | 1.4 | |
Hb (mg dl−1) | Control | 8.9 | 0.5 | 9.1 | 0.5 | 9.3 | 0.5 | 8.9 | 0.5 | 8.8 | 0.5 |
8-SPT | 8.9 | 0.2 | 8.5 | 0.3 | 9.2 | 0.2 | 8.7 | 0.2 | 8.5 | 0.3 | |
DPCPX | 8.8 | 0.3 | 9.1 | 0.3 | 9.7 | 0.3 | 9.6 | 0.4 | 8.7 | 0.4 | |
O2 content (mm) | Control | 3.6 | 0.3 | 3.4 | 0.2 | 1.7 | 0.1* | 3.3 | 0.2 | 3.3 | 0.2 |
8-SPT | 3.5 | 0.2 | 3.3 | 0.3 | 1.4 | 0.1† | 3.2 | 0.3 | 3.3 | 0.3 | |
DPCPX | 3.5 | 0.2 | 3.3 | 0.3 | 2.0 | 0.2† | 3.4 | 0.4 | 3.5 | 0.3 | |
PCO2 (mmHg) | Control | 50.1 | 1.8 | 50.1 | 2.2 | 44.0 | 1.9* | 48.0 | 2.6 | 48.0 | 2.6 |
8-SPT | 48.6 | 1.4 | 49.2 | 2.0 | 44.3 | 2.0* | 48.9 | 1.5 | 42.0 | 1.5 | |
DPCPX | 47.3 | 1.2 | 46.7 | 2.1 | 46.6 | 3.2 | 47.4 | 2.0 | 54.0 | 2.0 | |
pH | Control | 7.36 | 0.01 | 7.34 | 0.02 | 7.34 | 0.03 | 7.28 | 0.03* | 7.31 | 0.03 |
8-SPT | 7.36 | 0.01 | 7.35 | 0.01 | 7.37 | 0.02 | 7.26 | 0.02† | 7.31 | 0.02* | |
DPCPX | 7.37 | 0.01 | 7.36 | 0.02 | 7.32 | 0.03* | 7.26 | 0.02† | 7.26 | 0.03† | |
Glucose (mm) | Control | 1.04 | 0.14 | 1.13 | 0.16 | 1.19 | 0.11 | 1.34 | 0.12† | 1.26 | 0.13† |
8-SPT | 0.97 | 0.22 | 1.02 | 0.25 | 1.20 | 0.20 | 1.52 | 0.21† | 1.38 | 0.25† | |
DPCPX | 0.98 | 0.07 | 1.17 | 0.09 | 1.51 | 0.08† | 1.63 | 0.11† | 1.53 | 0.16† | |
Lactate (mm) | Control | 1.39 | 0.25 | 1.79 | 0.45 | 3.74 | 0.93 | 5.40 | 1.13† | 4.26 | 1.20* |
8-SPT | 1.53 | 0.22 | 1.56 | 0.22 | 3.54 | 0.53 | 6.11 | 1.06† | 4.52 | 0.97* | |
DPCPX | 1.06 | 0.05 | 2.03 | 0.32 | 4.74 | 0.62 | 7.10 | 0.73† | 6.61 | 0.64† |
Significant difference from baseline value (P < 0.05);
significant difference from baseline value (P < 0.01).