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. 2003 Oct 10;553(Pt 3):911–924. doi: 10.1113/jphysiol.2003.053140

Figure 7. Effect of the muscarinic antagonist 4-DAMP and hexamethonium on vasodilatation evoked by balloon distension or mucosal stroking.

Figure 7

A, left, representative trace of preconstsricted arteriole showing balloon distension (arrowhead; 3 distensions, ≈1 Hz) in the presence of 4-DAMP (1 μm) does not evoke vasodilatation. Following a 10 min washout of 4-DAMP, dilatation was evoked by repeat distension. Right, a representative trace of a preconstricted arteriole from a separate preparation showing vasodilatation in response to mucosal stroking (arrowhead; 4 strokes, ≈1 Hz) is blocked by 4-DAMP and that following washout, stroking can elicit a dilatation. Resting outside diameters were 46 μm (left) and 54 μm (right) **P = 0.02. B, summary of the percentage of mean peak dilatations in the presence of 4-DAMP and following washout for balloon distensions (left, n = 3) and mucosal stroking (right, n = 5). C, summary of the percentage of mean peak dilatations in the presence of hexamathonium (Hex, 300 μm) and following washout for balloon distension (left, n = 6) and mucosal stroking (right, n = 9) *P < 0.05.