Figure 7. Effects of inhibition of NO synthesis on MMCs recorded from +/+ and W/W^v mouse ileum.

A, B and C, a recording of mechanical activity in the proximal, mid and distal ileum, respectively, in a +/+ mouse. MMCs occurred about every 4 min. The period represented by the hatched bar shows the point of application of l-NA (100 μm), where the resting tone increased and the interval between MMCs decreased at each point in the ileum. D, E and F, a typical example recording of mechanical activity from W/W^v mouse ileum. l-NA also increased the resting tension at each site along the ileum and decreased the interval between MMCs.