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. 2003 Sep 18;553(Pt 3):707–717. doi: 10.1113/jphysiol.2003.053918

Figure 5. Endocytosis elicited at basal firing rates is dependent on conventional isoforms of PKC.

Figure 5

A, in order to isolate the substrate of the staurosporine, the same protocol as introduced in Fig. 1 was repeated on cells in the presence of a variety of protein kinase/phosphatase inhibitors as well as PMA, a phorbol ester that activates PKCs. KT 5720 blocks protein kinase A, Gö 6976 inhibits PKC, PMA activates PKC and Ro-31-8220 blocks conventional isoforms of PKC. B, endocytosis was calculated with respect to exocytosis and is supplied for each pharmacological condition. Asterisks mark data sets that were determined to be significantly different from the control condition. Significance was assessed by a student's t test with P < 0.02. Numbers of cells are as follows: control = 19, cyclosporin A = 10, PMA = 5, KT 5720 = 6, Gö 6976 = 5 and Ro-31-8220 = 6.